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曾昕 副教授

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曾昕

职称:副教授

学历/学位:研究生/博士

毕业院校/专业:江学院学/发酵工程

电子邮箱:xzenghsd@163.com; xzenghsd@126.com

 

简介:淮北体育大学相山学者,日照市创新领军人才,长期从事发酵食品、微生物源生物防腐剂的发酵合成、生防产品高效生物制造、发酵黑茶品质提升及保健功能研究,承担《生物工程设备与设计》、《现代工业发酵调控学》、《氨基酸工艺学》、《微生物工程实验》、《生物工艺学实验》、《生物工程综合实验》等课程的教学。发表论文30余篇,申请国家发明专利10余项,其中已授权7项,3项完成成果转化,主持国家自然科学面上项目、国家自然科学青年基金项目、安徽省自然科学基金面上项目、安徽省高校自然科学基金重点项目、省部级重点实验室开放项目、市级重点研发项目、企业横向课题等11项,目前担任Applied Microbiology and Biotechnology、Frontiers in Microbiology、Frontiers in Nutrition、Frontiers in Bioengineering and Biotechnology、Process Biochemistry等期刊审稿专家。

 

学习工作经历:

2020-至今 淮北体育大学,副教授、硕士生导师

2016-2020 淮北体育大学,讲师

2010-2016 江学院学,发酵工程,工学博士(硕博连读)

 

主要成果:

1、论文发表情况(第一或通讯作者):

(1) Mingzhi Zhu, Bohao Shang, Fang Zhou, Yong Yuan, Feiyan Yin, Jin Cao, Jianan Huang, Kunbo Wang, Xin Zeng*, Maiquan Li*, Zhonghua Liu*, Polysaccharides of Aspergillus cristatus isolated from Fu-brick tea attenuate obesity by regulating gut microbiota and gut microbiota-related metabolites, Food Science and Human Wellness, 2023, 13(3): 1513-1530.

(2) Long Pan, Cunjin Zhang, Xinyu Yuan, Yu Zhang, Xusheng Chen, Cuizhu Tian, Zishan Zhang, Mengqing Tian, Aimei Liao, Guanghai Yu, Ming Hui, Xin Zeng*, Jihong Huang*, Improvement of ε-poly-l-lysine production by co-culture fermentation strategy, Fermentation-Basel, 2023, 9(7), 626.

(3) Chaoping Yue#, Zhiwei Su#, Baoyan Tai, Hui Tang, Wangbao Da, Hongli Xu, Huawei Zeng, Bingyue Xin, Xin Zeng*, Physiological analysis of the improved ε-polylysine production induced by reactive oxygen species, Applied Microbiology and Biotechnology, 2023, 107, 881–896.

(4) Xin Zeng#*, Chen Zhang#, Chaoping Yue, Zhiwei Su, Baoyan Tai, Hui Tang, Huawei Zeng, Bingyue Xin, Mingzhi Zhu*, Transcriptome and metabolome analysis revealing the improved epsilon-poly-L-lysine production induced by a microbial call from Botrytis cinerea, Applied and Environmental Microbiology, 2022, 88 (20), e00952-22.

(5) Xin Zeng#, Chaoping Yue#, Zixian Ding#, Lulin Wang, Zhiwei Su, Huawei Zeng, Biao Zhang, Feng Li*, Mingzhi Zhu*, Waste cooking oil: new efficient carbon source for natamycin production by Streptomyces gilvosporeus Z8, Process Biochemistry, 2022, 118: 294–306.

(6) Chaoping Yue#, Haitao Xu#, Yingying Yu, Xin Yu, Min Yu, Chen Zhang, Qian You, Shaofan Xia, Zixian Ding, Hao Fu, Xin Zeng*, Feng Li*, Improvement of natamycin production by controlling the morphology of Streptomyces gilvosporeus Z8 with microparticle talc in seed preculture, Journal of Chemical Technology and Biotechnology, 2021, 96: 1533–1542.

(7) Mingzhi Zhu, Dan-min Lu, Jian Ouyang, Fang Zhou, Peifang Huang, Baozheng Gu, Junwei Tang, Fan Shen, Jiafeng Li, Yilong Li, Haiyan Lin, Juan Li, Xin Zeng*, Jianlin Wu, Shu-xian Cai, Kun-bo Wang, Jianan Huang, Zhonghua Liu*, Tea consumption and colorectal cancer risk: a meta-analysis of prospective cohort studies, European Journal of Nutrition, 2020, 59:3603-3615.

(8) Xin Zeng#, Huawei Zeng#, Yi Meng, Dayong Xu, Biao Zhang, Bingyue Xin, Shuai Liu, Bo Zhai, Feiyang Yu, Mingzhi Zhu*, Feng Li*, Continuous natamycin production by using immobilized Streptomyces gilvosporeus Z8 via repeated batch culture, Journal of Chemical Technology and Biotechnology, 2019, 95:73-77.

(9) Xin Zeng#, Wenyun Miao#, Beibei Wen, Zhonggui Mao, Mingzhi Zhu*, Xusheng Chen*. Transcriptional study of the enhanced ε-poly-L-lysine productivity in culture using glucose and glycerol as a mixed carbon source, Bioprocess and Biosystems Engineering, 2019, 42, 555-566.

(10) Xin Zeng#, Wenyun Miao#, Huawei Zeng, Kuo Zhao, Yaling Zhou, Juan Zhang, Qinxue Zhao, Delinur Tursun, Dayong Xu*, Feng Li*, Production of natamycin by Streptomyces gilvosporeus Z28 through solid-state fermentation using agro-industrial residues, Bioresource Technology, 2019, 273: 377-385.

(11) Xin Zeng, Junjie Zhao, Xusheng Chen*, Zhonggui Mao*, Wenyun Miao, Insights into the simultaneous utilization of glucose and glycerol by Streptomyces albulus M-Z18 for high ε-poly-L-lysine productivity, Bioprocess and Biosystems Engineering, 2017, 40: 1775-1785.

(12) Xin Zeng, Xusheng Chen*, Xidong Ren, Liang Wang, Yang Gao, Zhonggui Mao*, Improved ε-poly-L-lysine productivity partly resulting from rapid cell growth in culture using a glucose-glycerol mixed carbon source, Engineering in Life Sciences, 2016, 16: 443-452.

(13) Xin Zeng, Xusheng Chen*, Yang Gao, Xidong Ren, Liang Wang, Zhonggui Mao*, Continuously high reactive oxygen species generation decreased the specific ε-poly-L-lysine formation rate in fed-batch fermentation using glucose and glycerol as a mixed carbon source, Process Biochemistry, 2015, 50: 1993-2003.

(14) Xin Zeng, Xusheng Chen*, Xidong Ren, Qingrui Liu, Liang Wang, Qixing Sun, Lei Tang, Zhonggui Mao*, Insights into the role of glucose and glycerol as a mixed carbon source in the improvement of ε-poly-L-lysine productivity, Applied Biochemistry and Biotechnology, 2014, 173:2211-2224.

 

2、授权发明专利情况(第一发明人):

(1)曾昕等,一种基于发酵废菌渣交互回用的ε-聚赖氨酸-纳他霉素协同生产方法;专利号:ZL202110618978.4

(2)曾昕一种基于柠檬酸发酵废弃物的聚赖氨酸生物合成方法;专利号:ZL202110618983.5

(3)曾昕,一种利用霉变水果为碳源发酵合成ε-聚赖氨酸的方法,专利号:ZL202110618602.3

(4)曾昕,一种添加微生物诱导子的ε-聚赖氨酸生物合成方法,专利号:ZL202110618607.6

(5)曾昕,一种基于外源饱和脂肪酸添加的纳他霉素发酵工艺,专利号:ZL201910369887.4 (已完成技术成果转化)

(6)曾昕,一种基于细胞固定化技术的纳他霉素发酵工艺,专利号:ZL201910369890.6 (已完成技术成果转化)

(7)曾昕,一种利用工农业副产物固态发酵合成那他霉素的方法,专利号:ZL201811230431.1 (已完成技术成果转化)

 

3正在实审发明专利(第一发明人):

(1)一种基于链霉菌混合发酵合成纳他霉素的方法;专利号:202211398321.2;

(2)一种链霉菌-霉菌混合发酵合成ε-聚赖氨酸的工艺;专利号:202211398323.1;

(3)一种半固态发酵合成ε-聚赖氨酸的方法;专利号:202211443897.6;

(4)一种基于菌丝球结构调控的纳他霉素合成工艺;专利号:201910369891.0

 

4、主持项目情况:

(1)国家自然科学基金面上项目32372308,2024-2027,在研

(2)安徽省高校自然科学基金重点项目,2023AH050327,2024-2025在研

(3)国家自然科学基金青年基金项目,31901672,2020-2022,已结题

(4)安徽省自然科学基金面上项目,1908085MC57,2019-2022,已结题

(5)安徽省高校自然科学基金重点项目,KJ2020A0042,2020-2022,已结题

(6)湖南省作物种质创新与资源利用重点实验室科学基金开放项目,19KFXM06,2020-2022,已结题

(7)淮北市2019年科技重大专项子课题,2019-2022,已结题

(8)日照市2021年重点研发项目子课题,2021ZDYF010117,2022-2024,在研

(9)日照市2022年第二批创新领军人才团队项目,C类,在研

(10)江学院学工业生物技术教育部重点实验2022年度开放课题,KLIB-KF202206,2022-2023,在研

(11)横向项目,中国农科院植保所,2023-2025,在研

 

5、获奖情况:

(1)日照市第二批创新领军人才(C类)

(2)淮北体育大学青年相山学者

(3)2020年院级优秀共产党员

(4)2017-2018学年度本科生优秀指导教师

(5)2017年专业实习优秀指导教师

 

6、指导学生项目及获奖情况:

(1)安徽省大学生创新创业计划项目(2018、2019、2020、2021、2022年)

(2)2023年国家级大学生创新创业计划项目

(3)第九届安徽省“互联网+”大学生创新创业大赛银奖

(4)第十届“挑战杯”安徽省大学生课外学术科技作品竞赛三等奖

(5)第八届全国大学生生命科学竞赛(创新创业类)三等奖2项

(6)2023年安徽省大学生生态环境创新创业大赛三等奖

(7)淮北体育大学九届“学术新锐”研究生论坛二等奖

(8)第二届创业安徽大赛淮北赛区选拔赛优秀奖

(9)第九届“互联网+”大学生创新创业大赛淮北体育大学校级选拔赛一等奖

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